Genomic Tests for Ovarian Cancer Detection and Management, Evidence Report/Technology Assessment

QualityTool

Genomic Tests for Ovarian Cancer Detection and Management, Evidence Report/Technology Assessment

Description

This report assesses the evidence that the use of genomic tests for ovarian cancer screening, diagnosis, and treatment leads to improved outcomes. The authors conducted a literature review and constructed a computer simulation model to test the impact of different assumptions about ovarian cancer natural history on the relative effectiveness of different strategies.

This report includes the following sections:

  • Introduction
    • Ovarian cancer
    • Approaches to reducing ovarian cancer morbidity and mortality
      • Primary prevention in the entire population
      • Primary prevention in women at increased risk for developing ovarian cancer
      • Secondary prevention through screening
      • Secondary prevention through screening in women at high risk
      • Improved therapy after diagnosis of ovarian cancer
    • Genomic tests
      • Tests measuring single gene products
      • Tests for variations in DNA
      • Gene expression
      • Proteomics/protein characterization
    • Interest in genomic tests for ovarian cancer
    • Use of genomic tests in prevention of ovarian cancer morbidity and mortality
  • Methods
  • Results
    • Question 1: Analytic validity of testing
    • Question 2: Sensitivity and specificity of tests
    • Question 3: Impact on clinical management of asymptomatic patients
    • Question 4: Impact on clinical management of diagnosed patients
    • Question 5: Harms of using genomic tests
    • Question 6: Direct-to-consumer and direct-to-physician marketing
    • Modeling results
  • Discussion
    • Limitations of the report
    • Methodological issues in the literature
    • Implications of findings
  • Future research
  • Conclusions

Developer:

Duke University Evidence-based Practice Center (EPC)

Funding Sources:

Agency for Healthcare Research and Quality; Centers for Disease Control and Prevention

History

Release Date: 2006
Original Summary: December 2006
Last Updated: 07/11/12

QualityTool Classification

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