Comparative Effectiveness of Management Strategies for Gastroesophageal Reflux Disease

QualityTool

Comparative Effectiveness of Management Strategies for Gastroesophageal Reflux Disease

Description

This 108-page report examines alternatives for managing the chronic symptoms of uncomplicated gastroesophageal reflux disease (GERD) in patients who may require long-term treatment. It summarizes the available evidence comparing the efficacy and safety of medical, surgical, and endoscopic interventions in the treatment of chronic GERD, particularly after long-term followup.

This report addresses the following questions:

  • What is the evidence of the comparative effectiveness of medical, surgical, and endoscopic treatments for improving objective and subjective outcomes in patients with chronic GERD? Is there evidence that effectiveness varies by specific techniques/procedures or medications?
  • Is there evidence that effectiveness of medical, surgical, and endoscopic treatments varies for specific patient subgroups? What are the characteristics of patients who have undergone these therapies, including the nature of previous medical therapy, severity of symptoms, age, sex, weight, other demographic and medical factors, or by specific patient subgroups, and provider characteristics for procedures including provider volume and setting (e.g., academic versus community)?
  • What are the short- and long-term adverse effects associated with specific medical, surgical, and endoscopic therapies for GERD? Does the incidence of adverse effects vary with duration of followup, specific surgical intervention, or patient characteristics?

This report includes the following information:

  • Scope and key questions
  • Methods
    • Technical expert panel
    • Analytic framework
    • Search strategy
    • Study selection
    • Data extraction
    • Quality assessment
    • Data synthesis
    • Peer review
  • Results
    • Key questions 1A, 1B, 2A, 2B, and 3
  • Summary and discussion
  • Future research
  • References

Developer:

Tufts-New England Medical Center Evidence-based Practice Center (EPC)

Funding Sources:

Agency for Healthcare Research and Quality

History

Release Date: 2005
Original Summary: March 2006
Last Updated: 04/11/08

QualityTool Classification

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