2006 Update of ASCO Practice Guideline Recommendations for the Use of White Blood Cell Growth Factors: Guideline Summary

QualityTool

2006 Update of ASCO Practice Guideline Recommendations for the Use of White Blood Cell Growth Factors: Guideline Summary

Description

This six-page guideline summary is a 2006 update of the American Society of Clinical Oncology’s (ASCO) recommendations for the use of white blood cell growth factors.

This guideline summary addresses the following topics:

  • Primary prophylactic colony-stimulating factor (CSF) administration
  • Secondary prophylactic CSF administration
  • Therapeutic use of CSF
  • Use of CSF to increase chemotherapy dose intensity and dose density
  • Use of CSF as adjuncts to progenitor-cell transplantation
  • Use of CSF in patients with acute leukemia and myelodysplastic syndromes
  • Use of CSF in patients receiving radiotherapy with or without concurrent chemotherapy
  • Use of CSF in older patients (new topic)
  • Use of CSF in the pediatric population
  • CSF initiation, duration, dosing, and administration
  • Special comments on comparative clinical activity of G-CSF and GM-CSF
  • Special comments on growth factors as a treatment for radiation injury (new topic)
  • Impact of CSF on quality of life and health care costs
  • Clinical prediction and risk models

Four tables provide a summary the 2006 recommendations; a clinical prediction model for identifying patients at higher risk of complications; recommendations for CSF initiation, duration, dosing, and administration; and the incidence of hematologic and infectious toxicities associated with selected chemotherapy regimens. A summary of discussion and methodology, as well as information about additional resources, are also presented.

Developer:

American Society of Clinical Oncology

Funding Sources:

American Society of Clinical Oncology

History

Release Date: 2006
Original Summary: August 2006
Last Updated: 04/10/13

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